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Bupropion inhibits the reuptake of dopamine through the human dopamine transporter and norepinephrine transporter; 79 80 81 the inhibition of dopamine reuptake through the norepinephrine transporter is most pronounced in the prefrontal cortex of humans.

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The absolute bioavailability of bupropion is not known; excretion data in urine, however, show that at least 87 of the dose of bupropion is absorbed.

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